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Tamoxifeno Gdor 10mg by Astra Zeneca x 1 Strip

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$6.00
Weight:
10.00 Grams
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Product Description

The drug is approved by the U.S. Food and Drug Administration (FDA) to help treat early and advanced of breast cancer and prevent breast cancer (return). Tamoxifen is also FDA approved to help prevent breast cancer in women at high risk of the disease. Tamoxifen is an "anti-estrogen" and works by competing with estrogen to bind to estrogen receptors in breast cancer cells. By blocking the actions of estrogen in the breast tissue, tamoxifen helps slow the growth and reproduction of breast cancer cells.
While taking tamoxifen may benefit many breast cancer patients (and women at high risk of the disease), tamoxifen has also been shown to cause bothersome side effects in some women. In some instances, serious complications including deep vein thrombosis, endometrial cancer, and stroke may develop from tamoxifen use. Women should carefully discuss their specific risk factors for cardiovascular and other diseases with their physicians and assess the benefits and risks of taking tamoxifen for the treatment or prevention of breast cancer before beginning treatment.
This section discusses the possible side effects and complications from tamoxifen, and includes information on how women may cope with a number of these side effects.

Possible Side Effects of Tamoxifen
Though the overall occurrence of side effects is relatively low among women who take tamoxifen, the following side effects have been reported. Many women only experience one or two of these side effects and some women do not experience any. Women who are considering tamoxifen should discuss all potential benefits and risks with their physicians prior to treatment. In many cases, the benefit of treating or preventing breast cancer with tamoxifen outweighs the risk of these side effects.
Hot flashes and other menopausal symptoms: The most commonly reported side effect among women who take tamoxifen is a higher occurrence of hot flashes (approximately 50% of women on tamoxifen experience hot flashes when compared with a placebo, an inactive pill). Hot flashes may be accompanied by sweating, flushing, or heart palpitations. Hot flashes occur when estrogen is blocked in the hypothalamus, the part of the brain that controls the body's thermostat. Some women find that regular exercise can help reduce hot flashes. If the hot flashes are particularly bothersome and do not respond to conservative measures such as exercise, calcium, or other interventions, physicians may prescribe medications such as clonidine (brand name, Duraclon) or Megace (brand name, Megestrol). Physicians may also recommend taking 30 to 60-day "breaks" from tamoxifen to help reduce hot flashes and other menopausal symptoms.
It is important to note that hot flashes and other menopausal symptoms were also reported in women not taking tamoxifen (i.e., the placebo group) in the National Adjuvant Breast and Bowel Project's (NSABP) first Breast Cancer Prevention Trial. In this trial, 80% of women on tamoxifen experienced hot flashes while 68% of women who took a placebo (inactive pill) experienced hot flashes. Therefore, these symptoms may be related to menopause itself and not tamoxifen use. It is sometimes difficult to determine to what extent tamoxifen may contribute to these symptoms, as many women with a diagnosis of breast cancer are approaching menopause or they are post-menopausal.
Other reported menopausal symptoms in addition to hot flashes include vaginal dryness, mood changes, headaches, and irregular menstrual cycles. Women who experience vaginal dryness, irritation, or discharge are encouraged to ask their physicians about using vaginal lubricants to help relieve these symptoms. In some cases, vaginal discharge can be an indication of a more serious condition, such as endometrial cancer, and may require further investigation. Vaginal discharge was reported in 55% of women on tamoxifen in the NSABP's Breast Cancer Prevention Trial and in 35% of women who took a placebo (inactive pill).
Tamoxifen, by itself, does not cause permanent premature menopause in younger women (i.e., women in their thirties). For most young women who take tamoxifen, the ovaries continue to act normally and produce estrogen in the same or slightly increased amounts. In fact, some studies have suggested that tamoxifen may make pre-menopausal women more fertile. Therefore, precautions to avoid pregnancy should be taken if using tamoxifen when sexually active. Tamoxifen should not be taken during pregnancy.
Nausea or vomiting: Some women who take tamoxifen may experience nausea or vomiting while on the medication. Nausea and vomiting usually cease after the first few weeks on tamoxifen. Women who experience severe nausea and vomiting while taking tamoxifen should talk to their physicians about ways to relieve these symptoms.
Depression or mood changes: A small number of women who take tamoxifen experience sharp mood swings or become severely depressed. Since depression can come on slowly, over a period of several months, some women do not realize that they are depressed. It also may be difficult to determine whether tamoxifen is the source of the patient's depression or if other stress factors (such as coping with breast cancer and/or going through natural menopause) have contributed to the depression. Depending on the individual situation, depression may be treated with counseling or other medications. Some physicians will recommend taking 30 to 60-day "breaks" from tamoxifen to help relieve depression.
Weight gain: Large studies conducted by the (NSABP) revealed that women who took a placebo (inactive pill) were just as likely to gain weight as women who took tamoxifen. It is difficult to determine whether weight gain is caused by tamoxifen or by other factors, such as prior cancer treatment (especially certain regimens), changes in physical activity, changes in eating habits due to the stress of coping with breast cancer, etc. A few women who take tamoxifen experience weight loss.